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Sunday heralds the initial Wear-Tyne derby since 2024, but who will emerge victorious – Sunderland or the Magpies?
"Throughout the majority of last season, you couldn't have imagined Sunderland rising to the top flight and holding their own with Eddie Howe's Newcastle, much less being above them in the table," stated analyst Chris Sutton.
"The situation is very different now, and the way they play leads me to believe they've got a genuine opportunity."
He is offering predictions for all 380 Premier League games this season, in competition with artificial intelligence, the public and a variety of guests.
For week 16, he faces off against England Gaming star Daniel 'Stingray' Ray.
Ray is going for glory for the England's esports team – the Football Association's formal esports team – at the football simulation digital Euros finals tournament, which is being held at Twickenham Stadium on Saturday.
Viewers can catch Uefa's YouTube, IG Live and short-form video channels, as well as the official Twitch channel and its YouTube counterpart and the national team's Twitch.
Do you agree with their predictions? Share your own projections below.
The most popular scoreline chosen for each game is featured in the tables at the bottom of this page.
A correct result (choosing a win, draw or defeat) is worth ten points. The exact score earns forty points.
Ray, who also plays his club side and the Premier League champions as well as England, is making his debut at the eEuros finals after getting through the preliminary stage.
The final eight competitors will fly the flag at the finals in a single-elimination, competing for a substantial cash prize and a prestigious spot in the FC Pro World Championship Play-Ins, with Denmark's Anders Vejrgang defending the title he won last year.
"I am feeling really good for it," Ray stated. "I've got a really good coach alongside me and preparation has been going well.
"It's always an honour to play for your country. Of course when you are younger, you imagine doing it as an actual footballer, but when you go into this profession and there is an opportunity to represent England, wearing the Three Lions is something unique.
"I defeated Vejrgang 9-4 in qualifying to get here. I've played against him throughout the year just in practice, and in other tournaments before - but I'd never beaten him in a tournament before.
"In my opinion he is the number one in the world so beating him in a tournament like this just delivers a crazy boost of confidence."
Premier League Weekend Preview
Saturday, 13 December
Chelsea vs Everton
Stamford Bridge, 15:00 GMT
The Blues were excellent against the Gunners at the end of November, when they secured a point after going down to 10 men, and I was thinking they've turned a corner, they could possibly be challengers for the crown.
Since then, however, they were beaten physically by Leeds, looked uninspired against Bournemouth and this week got defeated by Atalanta in the Champions League.
So head coach Enzo Maresca is in need of a win here to restore momentum, but it won't be easy because the Merseyside club are such a dangerous team.
Their key midfielders are playing really well and they have got a bit of momentum at the moment.
Based on recent performances you would likely back the visitors, while the most sensible prediction would probably be a draw, but I'm going against logic.
The Blues have failed to given me any real reason to back them recently, but I just have a hunch they will emerge victorious because they are at home and they are due a win.
Sutton's prediction: 2-1
Stingray's prediction: With this being at the Bridge, I am going to back Chelsea. I think they will start off really well and go 2-0 up, then Everton will nick one back but then Chelsea score late. 3-1
AI's prediction: 2-0
Liverpool vs Brighton
Anfield, 15:00 GMT
I'll be at this game and it will be intriguing to see what we get from the Reds.
I am really pleased for Reds boss Arne Slot to get such a important victory at Inter Milan on Tuesday following all the stuff with Mohamed Salah this week.
Slot should not have to put up with that drama. I know Salah has been a legend for the club but at its core Slot just wants to win games and there is nothing personal in his team selection.
Liverpool changed their formation against Inter and went with a midfield diamond formation and two up top.
Everyone is going to be talking about whether Salah is selected for this game, but the only way he is going to be brought back into the fold is if he makes amends.
Slot's attention will be on winning this game, but it is a challenging encounter.
One might suggest it is the same for most teams but I find Brighton so unpredictable. I always feel they have got a goal in them, but they are quite open too.
Liverpool need to get back to a consistent run of form, but I am not sure how much their energy spent at the San Siro will have affected their stamina.
I put a couple of Brighton players in my Fantasy Premier League side, so they will likely do poorly - but I do think they can get something at Anfield.
Sutton's prediction: 2-2
Stingray's prediction: This is a game which is going to give Liverpool a bit more of their confidence back. Obviously they had a good win in midweek and they can build more momentum here. 2-1
AI's prediction: 3-1
Sunday, 14 December
Sunderland vs Newcastle
Stadium of Light, 14:00 GMT
The Wearside club have had the week off while Newcastle had to work so hard against Bayer Leverkusen on Wednesday, only to let their lead slip away late on.
Apart from their brilliant performance against Everton a couple of weeks ago, Newcastle's away form has been poor, particularly straight after they've played in the Champions League.
The pattern suggests that tendency to continue on Sunday, and their lack of freshness is likely to be a significant issue in how this game goes because of their rivals' high press.
It was evident how unwavering Regis le Bris's side are. They bullied the Gunners, and it was amazing to watch.
Commentators talks about how Granit Xhaka has been outstanding for the Black Cats, and he has been excellent, but Noah Sadiki, who plays next to him, has also been one of the top transfers and should be recognised too.
All signs point to this being the best game|most exciting fixture